Cystic fibrosis: current treatment and future direction
نویسندگان
چکیده
منابع مشابه
Cystic fibrosis: pathogenesis and future treatment strategies.
Since the detection of the underlying gene defect, our knowledge of how the genetic mutations in cystic fibrosis cause lung disease has increased substantially, but we still lack a complete understanding of some of the pieces in the puzzle. Nevertheless, the information gained has led to new therapeutic approaches that address key factors of cystic fibrosis pathophysiology. Past therapeutic suc...
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In patients with cystic fibrosis (CF) lung damage secondary to chronic infection is the main cause of death. Treatment of lung disease to reduce the impact of infection, inflammation and subsequent lung injury is therefore of major importance. Here we discuss the present status of antibiotic therapy for the major pathogens in CF airways, including prophylaxis against infection, eradication of e...
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Cystic fibrosis of the pancreas, the most frequently inherited disease affecting the Caucasian population, is an autosomal recessive disorder affecting principally the exocrine glands. It is of interest that despite the steadily increasing number of cellular and biochemical abnormalities reported in the disease even the most intrepid investigator has stopped short (sometimes only just) of staki...
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Malignant glioma is the most common primary brain tumor and accounts for the majority of diagnoses. Treatment has involved a combination of surgery, radiation, and chemotherapy, yet these modalities rarely extend the life of the patient to more than one year from diagnosis. Integrins are expressed in tumor cells and tumor endothelial cells, and are important in angiogenesis and invasion in glio...
متن کاملCystic fibrosis: a current review.
Cystic fibrosis (CF) is the most common severe genetic disorder seen in Caucasians. Defective exocrine gland secretions result in chronic diseases of the respiratory and gastrointestinal systems. However, the CF gene recently has been located and cloned. Currently, genetic technology allows identification of sibling carriers and antenatal diagnosis within families. Oral implications associated ...
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ژورنال
عنوان ژورنال: International Journal of Basic & Clinical Pharmacology
سال: 2021
ISSN: 2279-0780,2319-2003
DOI: 10.18203/2319-2003.ijbcp20211031